2009, discovery of a new phenotype for germs in slim nanofluidic slits; and to start with detection of nearby protein structures along DNA utilizing reliable-condition nanopores

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To be a human being, I hold the biblical assignment to examine and use every little thing in development for the good thing about my neighbour. I do not expertise any conflict involving religion and science. Quite the opposite, my religion stimulates me to complete science, to get open up-minded in the world.’

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on one molecules and metal clusters

2015, discovery that condensin can be a very flexible protein composition; and 1st detection of DNA knots making use of nanopores

Immediate immobilization of native yeast iso-one cytochrome c on bare gold: rapidly electron relay to redox enzymes and zeptomole protein-film voltammetry

Considering the fact that 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling reports of nucleosomes and DNA fix proteins to DNA translocation by way of nanopores. Not too long ago his research has centered on learning cell division with microbes on chip, even though his final interest is during the route of recognizing artificial cells.

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2003, demonstrated the very first biosensors made outside of a carbon nanotube; solved the framework and mechanism of DNA restore proteins; and discovery of a brand new technique for fabricating good-point out nanopores for DNA translocation

Dekker started off his investigation on single carbon nanotubes in 1993 when he arrange a different line of analysis to study electrical transportation via one organic and natural molecules in between nanoelectrodes. In 1996 a breakthrough was understood with carbon nanotubes. This was reached inside a collaboration While using the team of Nobel laureate Richard Smalley. STM and nanolithography methods were being accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with research from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. More not long ago his analysis has centered on learning chromatin composition and cell division with microbes on chip, although he is also aiming to ultimately Create synthetic cells from the bottom up.

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As an example, we look at the nucleopore elaborate, a gateway involving the cell nucleus and also the cytoplasm. This is a really intricate technique and ceesdekker thus difficult to review in the cell, so we use biomimetics. We reconstruct holes after which you can insert specific components of the nucleopore advanced to study transportation by means of it at the single-molecule stage.’

Dekker heeft fundamentele ontdekkingen gedaan op het gebied van koolstof nanobuisjes. Mede vanwege deze werkzaamheden is hij al jaren de meest geciteerde fysicus in Nederland. Tegenwoordig onderzoekt hij met enkel-molecuultechnieken de biofysica van moleculen in de biologische cel. Dekker is naast zijn wetenschappelijk werk ook bekend vanwege zijn belangstelling voor de relatie tussen geloof en wetenschap en de discussie rond smart structure in 2005. (nl)